316 papers
Molecular biology explores the tiny machinery inside living cells, revealing how genetic instructions are read, copied, and turned into the proteins that keep us alive. This field acts as a bridge between the static code of DNA and the dynamic processes that drive growth, disease, and life itself, offering insights into everything from cellular repair to the development of new medicines.
On Gist.Science, we track every new preprint uploaded to bioRxiv in this category to make these complex discoveries accessible to everyone. Our team processes each submission to provide both clear, plain-language explanations and detailed technical summaries, ensuring you can grasp the core findings without getting lost in dense academic jargon.
Below are the latest molecular biology papers freshly processed from bioRxiv, ready for you to explore and understand.
The paper introduces EVA, a long-context generative foundation model trained on over 114 million full-length RNA sequences that leverages a Mixture-of-Experts architecture to achieve state-of-the-art performance in deciphering RNA design principles and enabling versatile, controllable sequence engineering across diverse RNA classes.
This paper introduces GRASP, a transformation-independent CRISPR-based method that utilizes dCas9-gRNA ribonucleoprotein complexes to directly capture and purify specific chromatin loci from native plant nuclei, enabling efficient, sequence-specific isolation of genomic regions and their associated components without the need for transgenic expression.
This study demonstrates that dietary spermidine supplementation in farmed Atlantic salmon suppresses age-related adipose inflammation and restores metabolic flexibility by reprogramming lipid flux, while also establishing the species as a novel vertebrate model for studying metabolic ageing.
This study develops and validates a comprehensive molecular workflow comprising three highly sensitive real-time PCR assays and five Sanger primer sets to provide rapid, accurate, and verified species identification for the reemerging New World screwworm (*Cochliomyia hominivorax*), thereby enhancing surveillance capabilities for potential incursions into the United States.
This study identifies digoxin as a specific inhibitor of Bax{Delta}2-induced neuronal cell death that acts independently of its cardiac effects by modulating protein levels rather than aggregation, suggesting that structurally similar, safer compounds could be developed to treat Alzheimer's disease.
Using a rat model of MuSK myasthenia gravis, this study reveals that MuSK autoimmunity drives selective atrophy of slow-twitch muscle fibers through profound proteome remodeling characterized by disrupted mitochondrial and translational homeostasis, extending beyond mere neuromuscular junction impairment.
This study demonstrates a robust precision breeding strategy using CRISPR/Cas9, base editing, and prime editing to successfully integrate semi-dwarfing alleles into diverse Watkins wheat landraces, thereby unlocking their valuable genetic diversity for sustainable crop improvement.
This study reveals that extrachromosomal circular double-stranded DNA (eccDNA) constitutes a major component of stress granule cores and is essential for their formation during the eukaryotic stress response.
The authors developed a photocrosslinking activity-based probe using modified ubiquitin to map and validate interaction regions between E2 enzymes and diverse RING E3 ligases, thereby confirming existing structural models and assessing new ones in the absence of crystal structures.
This paper introduces a sample-derived cDNA-guided RNase H depletion method that selectively removes host RNA from infected tissues to enrich bacterial transcripts over 14-fold while preserving bacterial rRNA, thereby enabling cost-effective, high-sensitivity in vivo pathogen transcriptomics.